Omega 7 activates SIRT1, anti-aging gene
SIRT1 activation has been reported to be the main mechanism of phytochemicals, e.g. resveratrol, quercetin, for anti-aging. As a promising anti-aging regulator. It plays a crucial role in anti-inflammation and anti-apoptosis by suppressing pro-inflammatory gene expression.
Other than phytochemicals, Omega 7, e.g. palmitoleic acid, have also been reported to activate the same anti-aging gene, SIRT 1. A study published in Applied Biological Chemical revealed that Omega 7 activated SIRT1 and subsequently reduced inflammation (downregulating NF-kB and MMP-1) in human keratinocyte cells. (Song et al., 2018) As a result, Omega 7 significantly upregulated Pro-collagen type 1 and elastin expression, suggesting it can help improve collagen and elastin synthesis. Apart from acting as a building block of skin, the rare and novel Omega 7 has been discovered to have the following benefits on beauty:
These results align with another clinical trial done with Omega 7-rich sea buckthorn oil, which was shown to improve skin hydration by 49%, skin elasticity by 26%, and reduce wrinkle by 9% in 60 women of 50 to 70 years old* (Yang et al., 2008). Moreover, it was also shown to modulate the fatty acid profile of skin, improving eczema symptoms, such as dryness, redness and itching (Yang, B., 1999).
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Clinically-supported Vegan, Omega 7 formula for Beauty
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Reference
Song, I., Gu, H., Han, H., Lee, N., Cha, J., Son, Y. and Kwon, J., 2018. Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation. Applied Biological Chemistry, [online] 61(4), pp.433-439. Available at: https://link.springer.com/article/10.1007/s13765-018-0377-1.
Yang, B., Bonfigli, A., Pagani, V., Isohanni, T., von-Knorring, Å., Jutila, A. and Judin, V. (2008). Effects of oral supplementation and topical application of supercritical CO2 extracted sea buckthorn oil on skin ageing of female subjects. Journal of Applied Cosmetology, [online] 27(1), pp.13-25. Available at: https://www.researchgate.net/publication/287943011_Effects_of_oral_supplementation_and_topical_application_of_supercritical_CO2_extracted_sea_buckthorn_oil_on_skin_ageing_of_female_subjects.
Yang, B., 1999. Effects of dietary supplementation with sea buckthorn (Hippophaë rhamnoides) seed and pulp oils on atopic dermatitis. The Journal of Nutritional Biochemistry, [online] 10(11), pp.622-630. Available at: https://pubmed.ncbi.nlm.nih.gov/15539258/.