New Study Reveals CyanthOx™ as a Key Protective Agent for Mitochondrial Function
YANGLING, CHINA – A groundbreaking study conducted by researchers from the College of Food Science and Engineering at Northwest A&F University, in collaboration with Puredia Limited, has uncovered significant protective effects of CyanthOx™, a Sea Buckthorn Proanthocyanidin complex, on mitochondrial functions in macrophages under oxidative stress caused by hydrogen peroxide (H2O2). The findings are published in the latest issue of Frontiers in Pharmacology.
Study Overview
The research team set out to explore the protective effects of CyanthOx™ on mitochondria, the energy powerhouses within cells that are crucial for health and longevity. Using a variety of experimental techniques, including biochemical assays, fluorescence microscopy, and electron microscopy, the team studied the impact of CyanthOx™ on mitochondrial function under oxidative stress, a common cellular stress associated with many diseases.
Key Findings
Mitochondrial Protection: CyanthOx™ significantly increased mitochondrial membrane potential, inhibited the opening of mitochondrial permeability transition pores (mPTP), reduced mitochondrial swelling, and enhanced mitochondrial biosynthesis.
Activation of Cellular Pathways: The study revealed that CyanthOx™ activates the AMPK-PGC1α-Nrf2 pathway, enhancing the cell's ability to manage oxidative stress and maintain mitochondrial function.
Potential Health Implications: These findings suggest that CyanthOx™ could be effectively used in preventing and treating conditions associated with oxidative stress, such as cardiovascular diseases and aging-related disorders.
"The research highlights the potential of CyanthOx™, a major antioxidant component of the sea buckthorn plant, in safeguarding cells against oxidative damage, particularly in enhancing mitochondrial function and preventing diseases related to oxidative stress such as arteriosclerosis," explained Dr. Qiang Peng, the lead researcher of the study.
The study utilized a range of sophisticated techniques including Western blot analysis, mitochondrial membrane potential measurement, and electron microscopy to explore the effects of CyanthOx™ on cellular mitochondria. Results indicated that CyanthOx™ activates the AMPK-PGC1α-Nrf2 pathway, a critical signaling pathway for cellular energy regulation and antioxidant defense.
"By activating this pathway, CyanthOx™ helps maintain mitochondrial function even under conditions of oxidative stress, offering a promising avenue for the development of functional foods and cosmetics that could enhance cellular health and longevity," Dr. Peng added.
About Northwest A&F University
Northwest A&F University is recognized for its commitment to research excellence and innovation, especially in the areas of life sciences and technology. Located in Yangling, Shaanxi, China, the university is dedicated to addressing global challenges in food science, agriculture, and health.
About CyanthOx™
CyanthOx™ is a polyphenol-rich extract from the ancient sea buckthorn plant, including proanthocyanidins and flavonoids. Grown on the Tibetan Plateau, this unique blend is designed to dramatically reverse aging by enhancing cellular regeneration, boosting mitochondrial function, and providing superior antioxidant protection compared to traditional extracts. Ideal for combatting oxidative stress and aging, CyanthOx™ promotes overall cellular health and longevity.
About Puredia
Puredia is a global leader in the supply of organic, innovative, and clinically tested nutritional ingredients, specializing in the cultivation and development of Sea Buckthorn products. Established by Dr. Hywel Yuen, Puredia upholds rigorous international certification standards, including USDA, EU, Canada, and China Organic certifications, alongside Halal and Kosher accreditations. The company is distinguished by its robust commitment to scientific research, ensuring the highest levels of efficacy and safety in its offerings. Puredia's dedication to sustainability and social responsibility is evident in its management of organic-certified farms located on the Tibetan Plateau and its contributions to local communities, particularly in enhancing educational opportunities for children in surrounding areas.